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Anti-PD-L2 mAbs

简要描述:

This antibody binds human PD-L2, expressed on dendritic cells, IFN-gamma-treated monocytes, placental endothelium and medullary thymic epithelial cells.

产品参数:

Cat. No.:MABL-2659

Species:Engineer

Species Reactivity:Human

Type:Recombinate

Application:Block, ELISA, FC, IHC

详细介绍

Key features and   details


Cat. No.

MABL-2659

Name

Anti-PD-L2 mAbs

Clone No.

AFD- 24F.10C12

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Block, ELISA, FC, IHC

Species Reactivity

Human

Basic Information


Specificity

This antibody binds human PD-L2, expressed   on dendritic cells, IFN-gamma-treated monocytes, placental endothelium and   medullary thymic epithelial cells.

Alternative Name

CD273; PDL2; PDCD1LG2; PDCD1L2; PD-1 ligand   2; PDCD1 ligand 2; PDCD1 ligand 2; Programmed cell death 1 ligand 2;   Butyrophilin B7-DC; B7-DC

UniProt

Q9BQ51

Immunogen


Application Notes

This antibody can recognize PD-L2-Fc in an   ELISA. Flow cytometric analysis with whole anti-PD-L2 mAb 24F.10C12 and its   Fab version revealed approximately the same mean fluorescence intensity upon   binding PD-L2 transfected cells. This antibody is capable of blocking the   binding of PD-1-Ig to PD-L2 in a dose-dependent manner and with high avidity.  This antibody was also used for the immunohistochemical studies of various   tissues including thymus, germinal center, placenta, cardiac tissues, and   tumors. Blockade of PD-L2 on dendritic cells results in enhanced T cell   proliferation and cytokine production, including that of IFN-gamma and IL-10.   Both the whole antibody version and Fab version enhanced T cell activation,   showing that PD-L2 functions to inhibit T cell activation (PMID: 12538684).   This antibody was used for the study of PD-1 pathway on the activation of   naive, memory, and recently activated human CD4+ T cells (PMID: 15598424).

Antibody First   Published

Brown et al. Blockade of programmed death-1   ligands on dendritic cells enhances T cell activation and cytokine   production. J Immunol. (2003); 170(3):1257-66. PMID:12538684

Note on publication

Describes the generation of this antibody   and its tests its capability to block interaction between PD-1 and PD-L2 on   dendritic cells.

COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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