Anti-PD-L2 mAbs

Cat. No.

MABL-2660

Name

Anti-PD-L2 mAbs

Clone No.

AFD- 366C.9E5

From

Recombinant Antibody

Isotype

Engineer antibody

Application

IHC

Species Reactivity

Human

Basic Information

Specificity

This antibody is specific for human PD-L2,   and recognises an epitope in the IgV domain.

Alternative Name

CD273; Programmed cell death 1 ligand 2; PD-1 ligand 2; PDCD1 ligand 2; Programmed death ligand 2; Butyrophilin B7-DC; PDCD1LG2; B7DC; PDCD1L2; PD L2; 9E5

UniProt

Q9BQ51

Immunogen

This antibody was raised by immunising mice   with a recombinant protein fragment corresponding to the extracellular domain   of human PD-L2 (as an Ig fusion protein).

Application Notes

This antibody has been used in the immunohistochemical detection of PD-L2 in formalin-fixed, paraffin-embedded   tissue sections of Hodgkin's lymphoma tissue sections (Ansell et al, 2018;   Roemer et al, 2016), primary mediastinal large B-cell lymphoma and diffuse   large B-cell lymphoma biopsies (Shi et al, 2014; Chong et al, 2016),   non–small-cell lung cancer tumour samples (Calles et al, 2015), primary and   metastatic adenoid cystic carcinoma deposits (Sridharan et al, 2016), and tonsil and colorectal carcinoma tissue samples (Masugi et al, 2017).

Antibody First   Published

Shi et al. Expression of Programmed Cell   Death 1 Ligand 2 (PD-L2) is a Distinguishing Feature of Primary Mediastinal   (Thymic) Large B-cell Lymphoma and Associated with PDCD1LG2 Copy Gain Am J   Surg Pathol. 2014 Dec; 38(12): 1715–1723. PMID:25025450

Note on publication

The article describes the original use of   this antibody.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.