Key features and details | |
Cat. No. | MABL-3073 |
Name | Anti-TIGIT mAbs |
Clone No. | AFD- 1F4 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | |
Species Reactivity | Human, Mouse |
Basic Information | |
Specificity | The antibody is specific for human TIGIT. TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T- cell activation by promoting the generation of mature immunoregulatory dendritic cells. |
Alternative Name | T-Cell-Ig and ITIM domain; T-cell immunoreceptor with Ig and ITIM domains; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain- containing protein 3 |
UniProt | Q495A1 |
Immunogen | The original antibody was generated by immunizing hamsters with murine TIGIT-Fc fusion protein. |
Application Notes | |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
