Anti-4-1BB mAbs

Cat. No.

MABL-315

Name

Anti-4-1BB mAbs

Clone No.

AFD-BBK4

From

Recombinant Antibody

Isotype

Engineer antibody

Application

agonist, ELISA, FC

Species Reactivity

Human

Basic Information

Specificity

This antibody is specific for human   CD137.

Alternative Name

CD137; MGC2172; Tumor necrosis   factor receptor superfamily member 9; TNFRSF9; T cell antigen ILA;   Interleukin activated receptor; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; BBK-4

UniProt

Q07011

Immunogen

The original antibody was raised by   immunizing a mouse with CD137.

Application Notes

This antibody stimulates T-cell   activity (Son et al, 2004; pmid:15087232). ELISA was performed using this   antibody on E.coli expressed human 4-1BB (Son et al, 2004; pmid:15087232).   Mixed lymphocyte reaction was investigated with fresh peripheral blood mononuclear   cells using this antibody (Son et al, 2004; pmid:15087232). This antibody was   used for flow cytometry on a subline of human Jurkat 8-1 cells (Son et al,   2004; pmid:15087232). This antibody promoted long-term proliferation of PBMC   (Son et al, 2004; pmid:15087232).

Antibody First Published

Son et al. Humanization of agonistic   anti-human 4-1BB monoclonal antibody using a phage-displayed combinatorial   library. J Immunol Methods. 2004 Mar;286(1-2):187-201. PMID:15087232

Note on publication

The humanization of agonistic anti-human   4-1BB mAb, BBK-4, using a phage display library.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.