Key features and details | |
Cat. No. | MABL-316 |
Name | Anti-4-1BB mAbs |
Clone No. | AFD-LOB12.3 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Activate, FC |
Species Reactivity | Mouse |
Basic Information | |
Specificity | This antibody binds to mouse 4-1BB (CD137). |
Alternative Name | CD137; TNFRSF9; 41BB; 4-1BBL Ligand; Tumor necrosis factor superfamily member 9; TNF receptor superfamily member 9; LOB 12.3; LOB123; LOB12.3 |
UniProt | P20334 |
Immunogen | This antibody was generated by immunizing rats with recombinant CD137-Fc fusion protein. |
Application Notes | This antibody can be used to detect mouse 4-1BB (CD137). In its original rat IgG1 format, this antibody had agonistic effect and prolonged survival of mice bearing CT26 or A31 tumors. In the original publication another clone LOB12 disclosed which has a rat IgG2a isotype. This has led to some confusion in the literature with regards to the original isotype of LOB12 and LOB12.3. We offer this antibody in both formats as well as murine versions so that researchers may choose the isotype most appropriate for their assays. |
Antibody First Published | Taraban Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses. Eur J Immunol. 2002 Dec;32(12):3617-27 PMID:12516549 |
Note on publication | Describes the generation of this antibody and initial characterisation of its agonistic properties. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
