Key features and details | |
Cat. No. | MABL-328 |
Name | Anti-763.74 mAbs |
Clone No. | AFD- MK2-23 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Block |
Species Reactivity | n/a |
Basic Information | |
Specificity | |
Alternative Name | Ab763.74 idiotype; High molecular weight-associated melanoma antigenneutralising antibody 763.74 (anti-idiotype) |
UniProt | |
Immunogen | Monoclonal antibody 763.74. |
Application Notes | The antibody binds specifically to the monoclonal antibody 763.74. The 763.74 antibody has neutralising activity against HMW-MAA, a cell surface proteoglycan expressed on more than 90% of melanomas, which has been shown to contribute to the malignant transformation of cancer cells by inducing their invasion, growth and migration. The anti-idiotypic monoclonal antibody MK2-23 mimics HMWMAA in the binding to 763.67, and can thereby increase the level of antibody production against the antigen in patients with the melanoma. This induces a humoral immune response which has caused the regression of melanomas in some patients and can prolong their survival. |
Antibody First Published | Kusama et al. Characterization of syngeneic anti idiotypic monoclonal antibodies to murine anti-human high molecular weight melanoma-associated antigen monoclonal antibodies. J Immunol. 1989 Dec 1;143(11): 3844-52. PMID:2584721 |
Note on publication | Describes the generation of the MK2-23 monoclonal antibody against human high molecular weight melanoma-associated antigen (HMW-MAA) using the standard hybridoma technology. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
