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Anti-amyloid beta protein-bound GM1 mAbs

简要描述:

This antibody is specific for amyloid beta protein-bound GM1.

产品参数:

Cat. No.:MABL-405

Species:Engineer

Species Reactivity:Human

Type:Recombinate

Application:ThT fluorescence assay, ELISA

详细介绍

Key features and details

Cat. No.

MABL-405

Name

Anti-amyloid beta protein-bound GM1 mAbs

Clone No.

AFD- 3G11

From

Recombinant Antibody

Isotype

Engineer antibody

Application

ThT fluorescence assay, ELISA

Species Reactivity

Human

Basic Information

Specificity

This antibody is specific for amyloid beta   protein-bound GM1.

Alternative Name

GAβ

UniProt


Immunogen

The original antibody was generated by immunizing   Balb/c mice with synthesized GAβ.

Application Notes

The original antibody was generated and   screened in vitro via ELISA and Thioflavin T (ThT) fluorescence measurements for its ability to bind to GAβ and inhibit Aβ polymerization. It was assessed   in three polymerization systems  (1)   polymerization initiated by adding Aβ fibril fragment, (2) Aβ40   polymerization initiated from GAβ40, and (3) Aβ42 polymerization initiated   from GAβ42. It showed stronger inhibitory activity, particularly in Aβ40 and   Aβ42 polymerization systems, and was found to influence fibril length by   promoting fibril shortening or fragmentation rather than just preventing   elongation (US7741448B2).

Antibody First Published


Note on publication


COA Information For reference only, actual COA shall prevail

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.


 


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