Key features and details | |
Cat. No. | MABL-504 |
Name | Anti-Beta 2 adrenergic receptor mAbs |
Clone No. | AFD- 13D6 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | IP, WB, ELISA, IF |
Species Reactivity | Human |
Basic Information | |
Specificity | 13D6 antibody recognizes human beta-2 adrenergic receptor. It was reported that this antibody recognizes extracellualr domains of the receptor (Han et al., 2012). Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds adrenaline with far grater affinity than noradrenaline. |
Alternative Name | R11E1; Beta-2 adrenergic receptor; Beta-2 adrenoreceptor; Beta-2 adrenoceptor; β-2 adrenergic receptor; β-2 adrenoreceptor; β-2 adrenoceptor; β2AR; β2-AR; I3D6 |
UniProt | P07550 |
Immunogen | This antibody was raised by immunizing mice with beta-2 adrenergic receptor. |
Application Notes | This antibody is recommended for the identification and analysis of the β2-adrenergic receptor. For instance, tt was used to immunostain vascular smooth muscle cells (VSMCs) against beta-2- adrenergic receptor to determine the fate of beta-2ARs ubiquitinated in a carvedilol responsive manner (Han et al., 2012). Furthermore, the antibody was utilized in the quantification of the surface level of β- 2ARs via ELISA (Han et al., 2012). |
Antibody First Published | Han et al. MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors. J Cell Biol. 2012 Nov 26;199(5):817-30. doi: 10.1083/jcb.201208192. Epub 2012 Nov 19. PMID:23166351 |
Note on publication | This article describes the use and characterisation of this anti-β2-adrenergic receptor antibody. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
