Anti-BMP receptor type IA mAbs

Cat. No.

MABL-527

Name

Anti-BMP receptor type IA mAbs

Clone No.

AFD- AbD1556

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Blocking, SPR, ELISA

Species Reactivity

Human

Basic Information

Specificity

The antibody binds to human BMPR-IA with a low nanomolar affinity.

Alternative Name

BMPR-IA

UniProt

P36894

Immunogen

Biotinylated BMPR-IA immobilized on a resin.

Application Notes

This antibody binds to human BMPR-1A, which,   on ligand bindingg, forms a receptor complex acting as a serine/threonine  kinase, activating SMAD transcriptional regulators. They positively regulate   chondrocyte differentiation, for example. The antibody neutralizes   BMP-binding to the receptor.

Antibody First Published

Harth et al. A selection fit mechanism   in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity.   PLOS One 2010; 5(9)： e13049 PMID：20927405

Note on publication

Describes the generation of several anti   BMPR-IA antibodies and subsequent crystallisation as well as binding studies.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.