Key features and details | |
Cat. No. | MABL-646 |
Name | Anti-CCL2/CCL12 mAbs |
Clone No. | AFD- 11k2 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Block, ELISA |
Species Reactivity | Human, Mouse |
Basic Information | |
Specificity | Binds to human CCL2. |
Alternative Name | cytokine A2, MCP-1, Monocyte chemotactic factor 1, MCP-5, CCL12 |
UniProt | |
Immunogen | Human MCP-1. |
Application Notes | This antibody binds to human CCL2, a small cytokine that recruits monocytes, memory T cells and dendritic cells to the sites of inflammation. Can block monocyte chemotaxis in cell migration assays (PMID |
Antibody First Published | Lutgens E, Faber B, Schapira K, Evelo CT, van Haaften R, Heeneman S, Cleutjens KB, Bijnens AP, Beckers L, Porter JG, Mackay CR, Rennert P, Bailly V, Jarpe M, Dolinski B, Koteliansky V, de Fougerolles T, Daemen MJ. Gene Profiling in Atherosclerosis Reveals a Key Role for Small Inducible Cytokines Circulation. 2005 Jun 28;111(25):3443-52. Epub 2005 Jun 20. PMID:15967845 |
Note on publication | Describes time-related expression patterns in atherosclerosis and validation of the role of Mcps by generating and using the antibody 11k2. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
