Name
EDA2R Human
Cat. No.
MAG-5366
Tag/Conjugates
His
Source
Escherichia Coli.
Shipped
Shipped with Ice Packs
Description
EDA2R Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 161 amino acids (1-138 a.a) and having a molecular mass of 17.7kDa. EDA2R is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Synonyms
Ectodysplasin A2 Receptor, XEDAR, TNFRSF27, EDA-A2 Receptor, X-Linked Ectodysplasin-A2 Receptor, EDAA2R, EDA-A2R, Tumor Necrosis Factor Receptor Superfamily Member 27, Tumor Necrosis Factor Receptor Superfamily Member XEDAR, EDAR2.
Introduction
EDA2R (ectodysplasin A2 receptor) mediates the activation of the
NF-kappa-B and JNK pathways. Activation seems to be mediated through binding to
TRAF3 and TRAF6. In addition, Mutations in EDA give rise to a clinical syndrome
characterized by loss of hair, sweat glands, and teeth. EDA2R specifically
binds to EDA-A2 isoform. This protein is a type III transmembrane protein of
the TNFR (tumor necrosis factor receptor) superfamily, and contains 3
cysteine-rich repeats and a single transmembrane domain however it lacks an
N-terminal signal peptide. Alternatively spliced transcript variants have been found
for this gene. Among the diseases associated with EDA2R are ectodermal
dysplasia 1, hypohidrotic, x-linked, and hypohidrotic ectodermal dysplasia.
Physical Appearance
Sterile Filtered clear solution.
Formulation
EDA2R protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze thaw cycles.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGS MDCQENE YWDQWGRCVT CQRCGPGQEL SKDCGYGEGG DAYCTACPPR
RYKSSWGHHR CQSCITCAVI NRVQKVNCTA TSNAVCGDCL PRFYRKTRIG GLQDQECIPC TKQTPTSEVQ
CAFQLSLVEA DAPTVPPQEA T
Safety Data Sheet
SDS
Usage
Mabioway's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
