Name
MUC1 Human
Cat. No.
MAG-7453
Tag/Conjugates
His
Shipped
Shipped with Ice Packs
Description
The Human Mucin-1 (CA15-3) is having a molecular mass of approximately 400kDa, and was purified from human carcinoma cell line.
Introduction
Human Mucin-1 (CA15-3), aka MUC1, is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. This protein has alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit roles in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Mucins line the apical surface of epithelial cells in the stomach, lungs, intestines, eyes and other tissues. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. Overexpression of CA15-3 is often associated with colon, breast, ovarian, lung and pancreatic cancers.
Synonyms
/
Source
Human carcinoma cell line.
Physical Appearance
Clear to opalescent colorless frozen solution.
Solubility
/
Stability
Human MUC1 although stable at 4°C for 1 week, should be stored at -20°C.
Biological Activity
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Safety Data Sheet
SDS
Usage
Mabioway's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Formulation
MUC1 is supplied in a 0.05M sodium phosphate buffer, pH 7.5, 0.09% NaN3 and 0.15M NaCl.
Purity
Greater than 60%.
Human Virus Test
Tissue sample tested and found negative for HIV-1 & 2 antibodies, HBsAg, and Hepatitis-C antibodies, Syphilis and HIV/HBV/HCV NAT.
