Key features and details | |
Cat. No. | MABL-3453 |
Name | Anti-CD96 [6A6](MABL-3453) |
Clone No. | 6A6 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Blocking, FC |
Species Reactivity | Mouse |
Basic Information | |
Specificity | This antibody is specific for murine CD96, and recognises an epitope in the first Ig domain. |
Alternative Name | TACTILE; T-cell surface protein tactile; T cell-activated increased late expression protein |
UniProt | Q3U0X8 |
Immunogen | This antibody was raised by immunising rats with murine CD96. |
Application Notes | This antibody blocks murine CD96-CD155 interaction, and has been shown to bind to the first Ig domain of CD96 and compete with CD155 binding (Roman Aguilera et al, 2018). This antibody displays significant anti-metastatic activity in four experimental lung metastases models and one spontaneous tumour metastasis model (Roman Aguilera et al, 2018), with a potency greater than the anti- CD96 monoclonal antibodies 3.3 and 8B10. The binding specificity of this antibody has been determined in flow cytometric analysis of HEK-293 cells transfected with a range of CD96 Ig domain chimeric constructs (Roman Aguilera et al, 2018). |
Antibody First Published | Seth et al. The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1. Biochem Biophys Res Commun. 2007 Dec 28;364(4):959-65. PMID:17971293 |
Note on publication | Describes the original generation of this antibody, and its characterisation. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
