Name
EREG Human Protein
Cat. No.
MAG-1388
Tag/Conjugates
His
Source
Escherichia Coli.
Shipping
Shipped with Ice Packs
Description
EREG Human Recombinant produced in E.Coli is a single, non-glycosylated
polypeptide chain containing 69 amino acids (63-108 a.a) and having a molecular
mass of 7.7kDa. EREG is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Synonyms
Epiregulin, Proepiregulin, ER, ERP.
Introduction
Epiregulin is part of the EGF family. Epiregulin functions as a ligand of EGFR, as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors.Epiregulin is expressed mostly in the placenta and peripheral blood leukocytes and in specific carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. Epiregulin inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.
Biological Activity
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Physical Appearance
Sterile Filtered colorless solution.
Formulation
EREG protein solution (0.5mg/ml) containing 20mM Tris-HCl
buffer (pH8.0) and 10% glycerol.
Solubility
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Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity
Greater than 80.0% as determined by SDS-PAGE
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGS VSITKCS SDMNGYCLHG QCIYLVDMSQ NYCRCEVGYT GVRCEHFFL.
Usage
Mabioway's Co., Ltd products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Background
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