Cat. No.
MABL-028
Application
ELISA, IHC
Isotype
Engineer antibody
Species Reactivity
Clone No.
M45
From
Recombinant Antibody
Specificity
/
Alternative Names
MOG
UniProt
Immunogen
Rat MOG.
Application Notes
The antibody binds specifically to MOG, a transmembrane glycoprotein expressed on the surface of oligodendrocytes in the central nervous system, that plays an important role in maintaining the structure of the myelin sheath. Monoclonal antibodies that target MOG are involved in the pathogenesis of the demyelinating disorder multiple sclerosis (MS). Animals injected with anti-MOG antibodies have been shown to display symptoms of human MS, and can thereby be used as models to study the development of the disease. The monoclonal antibodies M45 and M3-24 bind to distinct epitopes on MOG.
Antibody First Published
von Büdingen HC, Hauser SL, Nabavi CB, Genain CP. Restrictive and diversifying elements of the anti-myelin/oligodendrocyte glycoprotein antibody response in primate experimental allergic encephalomyelitis. Immunogenetics. April 2006, Volume 58, Issue 2, pp 122-128 PMID:16528499
Note on publication
Describes the characterization of the expression of six monoclonal antibodies directed against MOG, in order to study the role of pathogenic autoantibodies in autoimmune diseases such as multiple sclerosis.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
