Cat. No.
MABL-027
Application
IP, WB, ELISA, IHC
Isotype
Engineer antibody
Species Reactivity
Hamster, Human
Clone No.
3F4
From
Recombinant Antibody
Specificity
/
Alternative Names
Major prion protein; p27-30; CD30 antigen; prion protein PrP; prion- related protein
UniProt
Immunogen
Hamster 263K PrPs.
Application Notes
The antibody binds specifically to prion, a misfolded protein that has the ability to enter healthy organisms and cause other misfolding of other proteins into their prion form. This plays an essential role in the pathogenesis of certain neurodegenerative disorders such as Creutzfeldt-Jakob disease (CJD), Gerstmann-Staussler syndrome (GSS) and bovine spongiform encephalopathy (BSE). These disorders are characterised by an accumulation of prion proteins in the brain, which have a disrupted secondary structure.
Antibody First Published
Kascsak RJ, Rubenstein R, Merz PA, Tonna-DeMasi M, Fersko R, Carp RI, Wisniewski HM, Diringer H. Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins. J Virol. 1987 Dec;61(12):3688-93. PMID:2446004
Note on publication
Describes the generation a species-specific monoclonal antibody directed against protease-resistant proteins (PrPs) in order to study the relationship of PrPs to their host precursor protein and to scrapie-associated fibril proteins.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
