Cat. No.
MABL-031
Application
WB, ELISA
Isotype
Engineer antibody
Species Reactivity
Species independent
Clone No.
12D4
From
Recombinant Antibody
Specificity
The antibody binds to morphine with an affinity (Kd) of 46 nM.
Alternative Names
Morphium; (5alpha,6alpha)-17-Methyl-7,8-didehydro-4,5- epoxymorphinan-3,6-diol
UniProt
Immunogen
Morphine-6-hemisuccinate conjugated with BSA.
Application Notes
The antibody binds specifically to morphine, an alkaloid opiate drug derived from the opium poppy administered for the management of narcotic pain. Morphine exerts its effects by binding to μ opiate receptors in the central nervous system and gastrointestinal tract, leading to analgesia and sedation, thereby increasing the patient's tolerance to pain. The monoclonal antibody 12D4 recognises the N-methyl to N-allyl substitution in the conversion of morphine to nalorphine.
Antibody First Published
Glasel JA, Bradbury WM, Venn RF. Properties of murine anti-morphine antibodies. Mol Immunol. 1983 Dec;20(12):1419-22. PMID:6361525
Note on publication
Describes the isolation of four high affinity monoclonal antibodies against morphine.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
