Cat. No.
MABL-087
Application
IB: IHC: IP
Isotype
Engineer antibody
Species Reactivity
Rat, Human, Mouse
Clone No.
L60/4
From
Recombinant Antibody
Specificity
This antibody is specific for Copper-transporting ATPase 1
Alternative Names
L60/4R; Menke's disease protein; Copper-transporting ATPase 1; Copper pump 1; Menkes disease-associated protein; MC1; MNK
UniProt
Q04656
Immunogen
This antibody was raised by immunising BALB/c mice with a synthetic peptide corresponding to the cytoplasmic N-terminus (amino acids 42-61) of human ATP7A.
Application Notes
This antibody has been used in immunoblot analysis of lysates from human skin fibroblasts, where it recognises a single band (Comstra et al, 2017). This band is missing in ATP7A null human Menkes fibroblasts. It has also been used in immunohistochemical analysis of adult rat hippocampus sections (Andrews et al, 2019; PMID:30667360).
Antibody First Published
Comstra et al. The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors eLife. 2017; 6: e24722. PMID:28355134
Note on publication
Describes the original use of this antibody.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
