Anti-Insulin-degrading Enzyme mAbs

Cat. No.

MABL-022

Name

Anti-Insulin-degrading Enzyme mAbs

Clone No.

AFD-Fab-IDE

From

Recombinant Antibody

Isotype

Engineer antibody

Application

ELISA

Species Reactivity

 Human

Basic Information

Specificity

Binds specificially to human IDE with a Kd   of 3.72 nM.

Alternative Name

IDE; Insulin Protease

UniProt

P14735

Immunogen

Human IDE.

Application Notes

This antibody binds human insulin degrading enzyme,   which breaks down insulin as well as amyloid peptides and is suggested to   play a role in both diabetes and Alzheimer's. Antibody binding does not   affect steady-state kinetics of IDE.

Antibody First Published

McCord et al. Conformational states   and recognition of amyloidogenic peptides of human insulin-degrading enzyme.   Proceedings of the National Academy of Sciences of the USA 2013;   110(34):13827-13832 PMID:23922390

Note on publication

Describes the generation of an antibody   against human IDE and crystallisation of the complex.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.