Key features and details | |
Cat. No. | MABL-023 |
Name | Anti-TrkA mAbs |
Clone No. | AFD-MNAC13 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Blocking, SPR, ELISA, IHC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds to the extracellular domain of TrkA. It was shown not to cross react with TrkB . Moreover MNAC13 is specific to TrkA with negligible reactivity to TrkB and TrkC. |
Alternative Name | Tropomyosin Receptor Kinase; NTRK1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; neurotrophic receptor tyrosine kinase 1; High Affinity Nerve Growth Factor Receptor; Tyrosine Kinase Receptor A |
UniProt | P04629 |
Immunogen | Human TrkA ECD. |
Application Notes | This antibody binds to human TrkA, a receptor tyrosine kinase involved in the development and the maturation of the CNS and the PNS through regulation of proliferation, differentiation, and survival of the sympathetic and nervous neurons. It is a receptor for NGF and phosphorylates several downstream proteins regulating a variety of signalling cascades. This antibody neutralizes the NGF-TrkA interation. |
Antibody First Published | Covaceuszach et al. Neutralization of NGR-TrkA receptor interaction by the novel antagonistic anti-TrkA monoclonal antibody MNAC13: A strcutural insight. Proteins 2005; 58(3):717- 727 PMID:15625712 |
Note on publication | Describes the characterisation of an antibody against human TrkA and demonstration of its neutralizing activity. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
