Key features and details | |
Cat. No. | MABL-156 |
Name | Anti-GABA(B)R2 mAbs |
Clone No. | AFD-N81/37.1 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | WB |
Species Reactivity | Rat, Human, Mouse |
Basic Information | |
Specificity | This antibody is specific for amino acids 861-912 of rat GABABR2. It shows no cross-reactivity against GABABR1. ABABR2 is a component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. |
Alternative Name | N81/37.1R; Gamma-aminobutyric acid type B receptor subunit 2; Gabbr2; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2; G-protein coupled receptor 51 |
UniProt | O88871 |
Immunogen | This antibody was raised by immunising BALB/c mice with fusion protein amino acids 861- 912 of rat GABABR2. |
Application Notes | This antibody has been used for a western blot on a protein sample in mice where S783 was mutated to alanine (S783A) (Terunuma et al, 2014; PMID:24431439). |
Antibody First Published | Terunuma et al. Postsynaptic GABAB receptor activity regulates excitatory neuronal architecture and spatial memory J Neurosci. 2014 Jan 15;34(3):804-16. PMID:24431439 |
Note on publication | Mice were created with enhanced postsynaptic GABABR signaling by mutating the serine 783 in receptor R2 subunit (S783A), which decreased GABABR degradation. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
