Anti-Co-Rest/RCOR1 mAbs

Cat. No.

MABL-213

Name

Anti-Co-Rest/RCOR1 mAbs

Clone No.

AFD-K72/8R

From

Recombinant Antibody

Isotype

Engineer antibody

Application

WB, IHC

Species Reactivity

Rat, Human, Mouse

Basic Information

Specificity

This antibody is specific for Co-Rest. Co-Rest is an essential component of the BHC complex, a corepressor   complex that represses transcription of neuron-specific genes in non-neuronal   cells.

Alternative Name

REST corepressor 1; RCOR1; Protein CoREST;   K72/8

UniProt

Q9UKL0

Immunogen

This antibody was raised against a fusion   protein of amino acids 109-293 of human Co-Rest.

Application Notes

This antibody was used in a western   blot of the olfactory epithelium of mice (Coleman et al, 2017;   PMID:28597915). Immunohistochemistry was preformed on the olfactory   epithelium of mice using this antibody (Coleman et al, 2017; PMID:28597915).

Antibody First Published

Coleman et al. Dissecting   LSD1-Dependent Neuronal Maturation in the Olfactory Epithelium J Comp Neurol.   2017 Nov 1;525(16):3391-3413. PMID:28597915

Note on publication

This study determined that LSD1 (1)   is expressed in early dividing cells before OR expression and neuronal   maturation and decreases at the time of OR stabilization; (2) colocalizes   with the repressor CoREST (also known as RCOR1) and histone deacetylase 2 in   these early dividing cells; and (3) is required for neuronal maturation   during a distinct time window between activating reserve stem cells   (horizontal basal cells) and Neurogenin1 (+) immediate neuronal precursors.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.