Anti-Vitamin D binding protein mAbs

Cat. No.

MABL-272

Name

Anti-Vitamin D binding protein  mAbs

Clone No.

AFD-6A2

From

Recombinant Antibody

Isotype

Engineer antibody

Application

in vivo, neutralize, ELISA

Species Reactivity

Mouse

Basic Information

Specificity

This antibody binds the mouse   vitamin D binding protein (VDBP). This protein is involved in the transport   and storage of vitamin D, scavenging of extracellular G-actin, enhancement of   the chemotactic activity of C5 alpha for neutrophils in inflammation and   macrophage activation.

Alternative Name

VDBP; GC; DBP; VDB; Vitamin D-binding   protein; Gc-globulin; Group- specific component

UniProt

P21614

Immunogen

The original antibody was generated   by immunizing New Zealand white rabbits with mouse vitamin D binding protein.

Application Notes

The binding characterization of this   antibody was done using ELISA. This antibody was capable of blocking vitamin   D binding protein and helps avoid damage to the synaptic plasticity of   neurons by restoring synaptic proteins like PSD95 and Synapsin I in mouse   groups treated with this antibody. This antibody was also capable of reducing   damage to the dendritic structure of neurons and protect against neuronal   damage in mouse groups treated with a combination of VDBP+6A2 (CN118754982).

Antibody First Published

Note on publication

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.