Key features and details | |
Cat. No. | MABL-303 |
Name | Anti-24P4C12 proteins mAbs |
Clone No. | AFD- Ha5-1(5)2.1 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody specifically binds to recombinant 24P4C12 expressing cells (PC3-24P4C12) and multiple cancer cell lines expressing 24P4C12. |
Alternative Name | |
UniProt | |
Immunogen | The original antibody was generated by immunizing of human γ2 producing XenoMice with RAT(E)-24P4C12 cells. |
Application Notes | This antibody was capable of binding cells expressing 24P4C12 proteins on their surface in a flow cytometric assay. This antibody can be used in the development of an antibody-drug conjugate for targeted delivery of toxins to cancerous cells. The cytotoxicity of Ha5-1(5)2.1-vcMMAE antibody-drug conjugates was evaluated in PC3 cells engineered to express 24P4C12 and it was reported that it can selectively deliver a cytotoxic drug to 24P4C12 expressing cells leading to their killing. Ha5- 1(5)2.1vcMMAE also inhibited the growth of subcutaneous and orthotopically established human androgenindependent prostate cancer xenograft in SCID mice (US8309093). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
