Key features and details | |
Cat. No. | MABL-3162 |
Name | Anti-Tyrosyl-tRNA synthetase mAbs |
Clone No. | AFD- NbA |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA |
Species Reactivity | Leishmania donovani |
Basic Information | |
Specificity | This antibody is specific for Leishmania donovani tyrosyl-tRNA synthetase. |
Alternative Name | LdTyrRS; Leishmania donovani tyrosyl-tRNA synthetase |
UniProt | |
Immunogen | The original antibody was generated by immunizing one llama (Lama glama) six times with in total 0.9 mg of LdTyrRS. Four days after the final boost, blood was taken to isolate peripheral blood lymphocytes. |
Application Notes | The specificity of this antibody's original format was confirmed by ELISA analysis. |
Antibody First Published | Barros-Álvarez et al. Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts Biochimie. 2017 Jul;138:124-136. doi: 10.1016/j.biochi.2017.04.006 PMID:28427904 |
Note on publication | The original publication focuses on the crystal structure of Leishmania donovani tyrosyl-tRNA synthetase (LdTyrRS) complexed with a nanobody and a tyrosyl adenylate analog, highlighting the flexibility of LdTyrRS, the interactions of the analog with the active site, and the presence of an "extra pocket" that can guide the development of selective drugs for treating infections caused by L. donovani and other pathogenic protozoa. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
