Key features and details | |
Cat. No. | MABL-706 |
Name | Anti-CD134 mAbs |
Clone No. | AFD- OX-40 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FACS, functional, IP, FC, IHC-Fr |
Species Reactivity | Rat |
Basic Information | |
Specificity | OX-40 antibody binds specifically to CD4+ T blasts. CD134 is a protein of the TNFR superfamily. It binds to OX40 ligand of both the monomeric and trimeric states which results in co- stimulated proliferation. |
Alternative Name | TNFRS4; Tumor necrosis factor receptor superfamily member 4; OX40 antigen; OX40L receptor; OX40; MRC OX40; MRC OX-40; OX-40 |
UniProt | P15725 |
Immunogen | OX40 antibody was prepared by immunizing mice with phytohaemagglutinin-activated rat lymph node cells. |
Application Notes | OX-40 antibody results in Fc-dependent (i.e. not Fab or F(ab')2) stimulation of in vitro activated T cell proliferation, but is not mitogenic for resting cells. This antibody can also label CD4+ T blasts and can pull down CD134/CD134+ cells. |
Antibody First Published | Paterson et al. Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol Immunol. 1987 Dec;24(12):1281-90. PMID:2828930 |
Note on publication | Describes the identification of and functional studies using antibodies which can act as markers for activated T cells. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
