Key features and details | |
Cat. No. | MABL-733 |
Name | Anti-CD156b mAbs |
Clone No. | AFD- hz1022C3 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | in vivo, ELISA, FC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is specific for the membrane proximal domain of ADAM17. |
Alternative Name | CSVP; TACE; ADAM17; ADAM 17; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; Disintegrin and metalloproteinase domain-containing protein 17 |
UniProt | P78536 |
Immunogen | The original antibody was raised by immunzing a BALB/c mouse with human ADAM17 recombinant protein and then humanizing the resulting antibody. |
Application Notes | The original antibody was used for an ELISA on human ADAM17 to determine its binding affinity. The antibody was used for flow cytometry on A172 human tumour cells to confirm that it could bind to cellular ADAM17. This antibody was used in vivo on mice in which A431 tumors were established, treatment with the antibody showed significant tumor inhibition and regression was observed in all animals, it achieved complete regression in two mice (US20180057601A1). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
