Cat. No.
MABL-981
Application
Depletion, IP, FC, IF
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
YTH24.5
From
Recombinant Antibody
Specificity
This antibody binds human CD45, the leukocyte common antigen, at epitope P2.
Alternative Names
leukocyte common antigen; LCA;CD45; Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen; L-CA; Itgb2; Lymphocyte antigen 5; Ly-5; T200; PTPRC; protein tyrosine phosphatase receptor type C
UniProt
P08575
Immunogen
Human T-cells injected into DA rats.
Application Notes
This antibody binds to and immunoprecipiates human CD45. In the original rat IgG2b format it was shown to trigger complement mediated lysis and synergizes with clone YTH54.12 (Ab00672) which binds a different epitope on human CD45.
Antibody First Published
Bidon et al. Therapeutic potential of monoclonal antibodies to the leukocyte- common antigen. Synergy and interference in complement-mediated lysis Transplantation. 1985 Nov;40(5):538-44. PMID:2414870
Note on publication
Describes generation and characterization of the synergistic effect of several anti- CD45 antibodies on lysis.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
