Cat. No.
MABL-986
Application
Depletion, IP, FC
Isotype
Engineer antibody
Species Reactivity
Dog
Clone No.
YKIX 753.22.2
From
Recombinant Antibody
Specificity
YKIX 753.22 binds specifically to CD45R. CD45R is an isoform of CD45 derived from alternative splicing from a single gene, and is expressed on B cells and peripheral T cells. When used in conjunction with YKIX 716.13, this antibody has been reported to promote cell depletion via antibody-dependent cell- mediated cytotoxicity.
Alternative Names
CPTPRC; D45 R; L-CA; Leukocyte common antigen; T200; B220; GP180; LCA; LY5; Ly-5; protein tyrosine phosphatase; receptor type C
UniProt
Immunogen
YKIX 753.22.2 was prepared by immunizing DA rats with canine thymocytes.
Application Notes
YKIX 753.22.2 can be used for FC and IP. It can also be used in conjunction with YKIX 716.13 to promote cell depletion via antibody-dependent cell-mediated cytotoxicity.
Antibody First Published
Cobbold et al. Monoclonal antibodies that define canine homologues of human CD antigens: summary of the First International Canine Leukocyte Antigen Workshop (CLAW). Tissue Antigens. 1994 Mar;43(3):137-54. PMID:8091414
Note on publication
Describes the binding specificity and characterisation (by IF staining and FACS, and IP) of antibodies against canine equivalents of human CD antigens.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
