Cat. No.
MABL-1307
Application
ELISA, FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
281F12
From
Recombinant Antibody
Specificity
This antibody is specific for CXCR4.
Alternative Names
CXC-R4; CXCR-4; C-X-C chemokine receptor type 4; fusin; CD184; 2S201E; FB22; HM89; HSY3RR; LAP-3; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM; WHIMS; WHIMS1; Leukocyte-derived seven transmembrane domain receptor
UniProt
P61073
Immunogen
Application Notes
The binding of the original version of this antibody (VHH) to CXCR4-expressing viral lipoparticles was characterized in an ELISA. Furthermore, it was analyzed for its ability to compete with the ligand CXCL12 (or SDF-1a) for receptor binding by displacement of biotinylated SDF-1 on Caki-CXCR4 cells in flow cytometry. This antibody exhibited medium/low potency (IC50 ≥ 10 nM). In its bi-specific construction with clone 57A07, it served a functional role (US20220242958).
Antibody First Published
Note on publication
The original publication describes the construction and characterization of various bi- specific antibodies.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
