Cat. No.
MABL-1317
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
AbAbNb01-CysC
From
Recombinant Antibody
Specificity
This antibody binds human cystatin C. This protein acts as an inhibitor of cysteine proteinases found in a variety of biological human fluids and secretions and acts as a regulator for its enzymatic activity. A mutation in the gene expressing cystatin C has been associated with amyloid angiopathy. This protein is secreted by all nucleated cells and is freely filtered by the glomerulus. Therefore, serum concentration of cystatin C has shown great clinical potential as a biomarker of acute kidney injury or to access renal function. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role as a marker in vascular disease evaluation.
Alternative Names
CysC; Cys C; CST3; Cystatin-C; Cystatin-3; Gamma-trace; Neuroendocrine basic polypeptide; Post-gamma-globulin; cysteine protease inhibitor C
UniProt
P01034
Immunogen
The original antibody was generated by immunizing a Xinjiang dromedary camel with recombinant human cystatin C. The antibody was isolated from an immune nanobody library generated from the peripheral blood of the immunized camel after panning against human cystatin C.
Application Notes
The binding reactivity of this antibody for human cystatin C was determined using ELISA. This antibody can be used for the analysis of serum concentration of cystatin C (CN103408667).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
