Cat. No.
MABL-1393
Application
Blocking, WB, ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
3E 3
From
Recombinant Antibody
Specificity
This antibody binds specifically to the extracellular domain of human DDR1.
Alternative Names
DDR1
UniProt
Q08345
Immunogen
Recombinant human DDR1 extracellular domain.
Application Notes
This antibody binds to human Discoidin Domain Receptor 1, a receptor tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates the attachemnt of the cell to the extracellular matrix. This receptor is required for blastocyst implantation during pregnancy, mammary gland differentiation as well as lactation. It promotes smooth muscle cell migration as well as tumour cell invasion. The antibody acts as an antagonist.
Antibody First Published
Carafoli et al. Structure of the discoidin domain receptor 1 ectracellular egion boudn to an inhibitory Fab fragment recelas features important for signalling. Structure 2012; 20(4):688-697 PMID: 22483115
Note on publication
Describes the generation of several antibodies against the discoidin domain receptor and subsequent crystallisation as well as binding studies.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
