Cat. No.
MABL-1408
Application
in vivo, inhibition, SPR, ELISA
Isotype
Engineer antibody
Species Reactivity
Human, Mouse
Clone No.
mh2F
From
Recombinant Antibody
Specificity
The antibody is specific for human and mouse DLL4.
Alternative Names
Delta-like protein 4; Drosophila Delta homolog 4 (Delta4)
UniProt
Q9NR61
Immunogen
Application Notes
The binding affinity of the antibody to DLL4 was measured by surface plasmon resonance (Kd= 5 nM). The specificity of the original format of the antibody for human and mouse DLL4 was confirmed by ELISA analysis. The antibody inhibited the binding between DLL4 and the Notch receptor, thereby inhibiting Notch signaling. The antibody was shown to reduce the size of the tumor in mice transplanted with human lung cancer cells A549 cells (KR1020140085790A).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
