Cat. No.
MABL-1434
Application
RIA, theraputic, ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
E-11-13
From
Recombinant Antibody
Specificity
The antibody is specific to human DR5, with a dissociation constant of 0.0729nm.
Alternative Names
TRAILR2; TNFRSF10B; TRAIL receptor 2; tumor necrosis factor receptor superfamily member 10B
UniProt
O14764
Immunogen
The antibody was raised in mice homozygous for both disrupted endogenous Ig heavy chain and k light chain, harboring a chromosome 14 fragment (SC20) containing a human Ig heavy chain locus and a human Igk chain transgene (KCo5). The mice were immunised against TRAIL-R1 and TRAIL-R2.
Application Notes
This antibody binds DR5, activation of which triggers apoptosis. Consequently, this antibody has shown anti-tumour activity in mice with subcutaneously transplanted colon carcinoma cells Colo205. The antibody has been shown to function in ELISA and RIA.
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
