Cat. No.
MABL-1435
Application
Blocking, ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
Fab-BDF1
From
Recombinant Antibody
Specificity
The antibody binds to human DR5 with nanomolar affinity. The original format of this antibody has an IC50-value of 2 nM.
Alternative Names
TRAIL receptor 2; Proapoptotic Death Receptor DR5; Death Receptor 5; TRAIL receptor 2; TRAILR2; Tumor Necrosis Factor Receptor Superfamily Meber 10B; TNFRSF10B
UniProt
Q9BY82
Immunogen
Human immobilized DR5.
Application Notes
The antibody binds to human DR5, a receptor that can be activated by tumor necrosis factor-related ligands and transduces apotposis signals. The antibody occludes the smaller of the two Apo2L/TRAIL binding sites on DR5
Antibody First Published
Li et al. Activation of the proapoptotic death receptor DR5 by oligomeric peptide and antibody agonists. Journal of Molecular Biology 2006; 361(3):522-36 PMID:16859704
Note on publication
Describes the use of phage display to generate a synthetic antibody against human proapoptotic death receptor DR5 and subsequent crystallography.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
