Cat. No.
MABL-1512
Application
functional assay, therapeutic
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
KB004
From
Recombinant Antibody
Specificity
This antibody is specific for human epha3 receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.
Alternative Names
Ephrin type-A receptor 3; EPH-like kinase 4; EK4; hEK4; HEK; Human embryo kinase; Tyrosine-protein kinase TYRO4; Tyrosine-protein kinase receptor ETK1; Eph-like tyrosine kinase 1
UniProt
P29320
Immunogen
This antibody was created by humanizing the IIIA4 antibody. The IIIA4 antibody was raised by immunizing mice with LK63 cells.
Application Notes
This antibody has been shown to have a wide therapeutic potential. Human version of this antibody was shown to be safe for treatment of patients with refractory hematologic malignancies (Swords et al, 2016; pmid:27736729). Further, it has been shown that this antibody was cytotoxic to LK63 cell lines (Charmsaz et al, 2017; pmid:27922598). Besides this, the antibody was also shown to reduce multiple myeloma angiogenesis (Caivano et al, 2017; pmid:28415715). Fianlly, this antibody has been observed to reduice lung fibrosis is mice (WO2018053032).
Antibody First Published
Boyd et al. Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line J Biol Chem. 1992 Feb 15;267(5):3262-7. PMID:1737782
Note on publication
Describes the generation and characterization of this antibody.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
