Cat. No.
MABL-1548
Application
radioimmunoassay, Block
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
RFF-VII/1
From
Recombinant Antibody
Specificity
This antibody is specific for human coagulation factor VII, a serine protease that initiates the extrinsic pathway of coagulation and circulates as a zymogen.
Alternative Names
Coagulation factor VII; factor-VII; EC:3.4.21.21; Proconvertin; Serum prothrombin conversion accelerator; SPCA; Eptacog alfa
UniProt
P08709
Immunogen
This antibody was raised by immunising Balb/c mice with purified human factor VII.
Application Notes
This antibody binds with high affinity to human factor VII, and acts as an inhibitor of factor VII coagulation activity (Takase et al, 1988).When coupled to sepharose, this antibody has been used to deplete factor VII from plasma (Sarial et al, 2012). The specificity of this antibody for factor VII has been confirmed in a double monoclonal immunoradiometric assay for factor VII antigen (Takase et al, 1988).
Antibody First Published
Takase et al. Monoclonal antibodies to human factor VII: a one step immunoradiometric assay for VII:Ag. J Clin Pathol. 1988 Mar;41(3):337-41. PMID:3360957
Note on publication
Describes the original generation and characterisation of this antibody.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
