Cat. No.
MABL-1569
Application
Blocking, in vitro, in vivo
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
h22-0015
From
Recombinant Antibody
Specificity
The antibody is specific for human FcRn. The neonatal Fc receptor is a cell surface receptor that transfers passive humoral immunity from the mother to the newborn.
Alternative Names
IgG receptor FcRn large subunit p51; FCGRT; IgG Fc fragment receptor transporter alpha chain; Neonatal Fc receptor
UniProt
P55899
Immunogen
The original antibody was generated by immunizing Balb/c mice with recombinant FcRn.
Application Notes
The antibody was employed in blocking experiments with HEK293 cells that overexpress FcRn. The results showed that the antibody has a good effect of blocking the binding of IgG to FcRn at the cellular level (IC50: 11.4nM). The effect of the antibody was tested in human FcRn transgenic mice. The antibody was able to increase IgG catabolism in vivo by blocking FcRn binding (CN113484526).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
