Cat. No.
MABL-1642
Application
Blocking, SPR, ELISA
Isotype
Engineer antibody
Species Reactivity
Entamoeba histolytica
Clone No.
CD33-LA22
From
Recombinant Antibody
Specificity
The antibody binds with a Kd of 3.51 nM.
Alternative Names
UniProt
C4LTM0
Immunogen
Peripheral Lymphocytes of an asymptomatic E. histolytica cyst passer.
Application Notes
This antibody binds to E. histolytica Gal/GalNAc lectin, which is a multifuctional virulence factor which is involved in adherence, cytolysis, invasion, resistance to lysis by complemenet and encystment. The antibody blocks the lectin.
Antibody First Published
Tachibana et al. VH3 gene usage in neutralizing human antibodies specific for the Entamoeba histolytica Gal/GalNAc lectin heavy subunit. Infection and Immunology 2003; 71(8):4313- 4319 PMID:12874307
Note on publication
Describes the generation of novel antibodies against amoebean antigens and shuffling of heavy- and light chains to optimise antigen-binding affinities.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
