Cat. No.
MABL-1676
Application
SPR
Isotype
Engineer antibody
Species Reactivity
Poliovirus type 1
Clone No.
VHH 10E
From
Recombinant Antibody
Specificity
This antibody is specific for the VP3 protein from the genome polyprotein of the poliovirus.
Alternative Names
Genome polyprotein; Capsid protein VP3; Virion protein 3
UniProt
P03300
Immunogen
The original antibody was raised by immunizing a dromedary with poliovirus type 1 Sabin strain.
Application Notes
The structure of the original antibody was determined using cryo-EM (Strauss et al., 2017; PMID：27852863). The binding strength of the original antibody to poliovirus antigens was determined using surface plasmon resonance (Thys et al., 2011; PMID：21371506).
Antibody First Published
Thys et al. In vitro antiviral activity of single domain antibody fragments against poliovirus Antiviral Res. 2010 Aug;87(2)：257-64 PMID：20566349
Note on publication
The original paper aimed to determine whether VHHs inhibit wild-type and vaccine strains of poliovirus type 1.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
