Cat. No.
MABL-1685
Application
in vitro, neutralizing, ELISA
Isotype
Engineer antibody
Species Reactivity
varicella zoster virus
Clone No.
RM-2D6
From
Recombinant Antibody
Specificity
The original antibody is specific for the gH of varicella-zoster virus.
Alternative Names
VZV; Envelope glycoprotein H
UniProt
Q775J3
Immunogen
The original antibody was generated by vaccinating seven subjects (60 to 71 years old) with Zostavax.
Application Notes
The specificity of the original format of the antibody was confirmed by ELISA analysis. The original format of the antibody was able to neutralize VZV in vitro (IC50 = 0.03 and 0.23 µg/ml, respectively, with and without complement). The original format of the antibody could inhibit cell-to-cell spread in vitro (Sullivan et al., 2018; PMID： 29743372).
Antibody First Published
Sullivan et al. Breadth and Functionality of Varicella-Zoster Virus Glycoprotein-Specific Antibodies Identified after Zostavax Vaccination in Humans. J Virol. 2018 Jun 29;92(14)：e00269-18. doi： 10.1128/JVI.00269-18. Print 2018 Jul 15. PMID：29743372
Note on publication
The original paper describes the generation and characterization of the antibody.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
