Cat. No.
MABL-2023
Application
in vivo, therapeutic, Block
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
CNTO 1275 (Ustekinumab)
From
Recombinant Antibody
Specificity
This antibody is specific for the p40 subunit of human IL-12/23.
Alternative Names
p40; IL-12; IL-12p40; IL-12B; IL-23; IL-23p40
UniProt
Immunogen
The original antibody was produced by immunizing human immunoglobulin transgenic mice ((CBA/J×C57/BL6/J) F2 hybrid) with human recombinant IL-12.
Application Notes
This antibody inhibits the interactions of IL-12 and IL-23 with the cell surface IL-12Rβ1 receptor and has been evaluated in phase I, II, and III trials as a treatment for immune-mediated diseases such as psoriasis, psoriatic arthritis, Crohn’s disease, multiple sclerosis, and ulcerative colitis (Elliott et al., 2009; PMID: 20074279) (Sands et al., 2019; PMID: 31553833).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
