Cat. No.
MABL-2035
Application
neutralize, SPR, Block, ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
MCAF5352A (Afasevikumab)
From
Recombinant Antibody
Specificity
This antibody is specific for human IL-17A and human IL-17F. It also binds their respective dimers — IL-17AA, IL-17AF, and IL-17FF.
Alternative Names
IL17; IL-17A; IL17A; CTLA8; Interleukin-17A; IL-17A; Cytotoxic T- lymphocyte-associated antigen 8; CTLA-8; IL17F; IL-17F; Interleukin-17F; IL-17F; Cytokine ML-1; IL-17AA; IL- 17AF; IL-17FF
UniProt
Immunogen
The original antibody was produced by immunizing HuMab® mice with human IL-17.
Application Notes
This antibody successfully completed phase I clinical trials (Mitra et al., 2014; PMID: 25398489). The pharmacokinetics of this antibody and the post-dose levels of IL-17AA and IL-17FF in healthy were assessed as part of the phase I study (Peng et al., 2018; PMID: 30547287). The crystal structure of the Fab version of this antibody was resolved, and its binding kinetics (KD) was measured at 7.78 ± 0.23 pM. Furthermore, alterations to the antibody's aromatic residues in its binding site and their effect on binding kinetics were assessed (Tilegenova et al., 2020; PMID: 31779513).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
