Key features and details | |
Cat. No. | MABL-948 |
Name | Anti-CD40 mAbs |
Clone No. | AFD- HB-14 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | FC, IF |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is specific for human CD40 |
Alternative Name | HB14; CD40; Bp50; CDw40; CD40L receptor; B-cell surface antigen CD40; Tumor necrosis factor receptor superfamily member 5 |
UniProt | P25942 |
Immunogen | The original antibody was raised by immunizing a mouse with human CD40. |
Application Notes | The original antibody was used for flow cytometry on B-NHL cells (Pantoja-Escobar et al, 2019; PMID:30277117), and on B cells from cynomolgus monkeys. The use of this antibody allowed for CD20-independent identification of a highly pure B-cell population (Mao et al., 2013; PMID:24265828). This antibody was used in flow cytometry for DC phenotype analysis of PBMCs and DCs (Wang et al., 2022; PMID:35149692). This antibody was used for immunofluorescence on human pancreatic islets. This antibody was able to show CD40 expression on these cells (Klein et al., 2005; PMID:15690148). |
Antibody First Published | Klein et al. A functional CD40 receptor is expressed in pancreatic beta cells Diabetologia. 2005 Feb;48(2):268-76 PMID:15690148 |
Note on publication | The original paper reports that in addition to immune cell types, mouse and human pancreatic beta cells express CD40. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
