Cat. No.
MABL-2250
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Bacillus anthracis
Clone No.
F3-6
From
Recombinant Antibody
Specificity
This antibody recognizes lethal factor (LF) of anthrax toxin. LF is the lethal factor that, when associated with PA, causes death. LF is not toxic by itself. It is a protease that cleaves the N-terminal of most dual specificity mitogen-activated protein kinase kinases (MAPKKs or MAP2Ks) (except for MAP2K5).
Alternative Names
lethal factor; LF; Anthrax lethal toxin endopeptidase component; anthrax toxin
UniProt
P15917
Immunogen
The original scFv version of this antibody was isolated from a phage display library generated from immunized chimpanzees.
Application Notes
The original scFv version of this antibody was confirmed to strongly bind anthrax lethal factor (LF) via ELISA (Chen et al., 2006; pmid: 16453257).
Antibody First Published
Chen et al. Efficient Neutralization of Anthrax Toxin by Chimpanzee Monoclonal Antibodies against Protective Antigen J Infect Dis. 2006 Mar 1; 193(5): 625–633. PMID:16453257
Note on publication
Describes the generation and characterization of anti-PA and anti-LF anthrax antibodies.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
