Cat. No.
MABL-2311
Application
neutralizing, SPR
Isotype
Engineer antibody
Species Reactivity
Human, Mouse
Clone No.
RX1
From
Recombinant Antibody
Specificity
The antibody is specific for M-CSF. The antibody binds to a linear epitope of M-CSF (amino acids 98-105).
Alternative Names
CSF-1; MCSF; PG-M-CSF; Lanimostim; Macrophage colony-stimulating factor; Macrophage colony-stimulating factor 1; Proteoglycan macrophage colony-stimulating factor
UniProt
P09603
Immunogen
Application Notes
The binding properties of the original format of the antibody were analyzed using SPR analyses (Kd = 0.16 nM). The antibody could neutralize human M-CSF activity, as measured by a proliferation assay with M-NFS-60 cell line. Further, the Fab fragment of the antibody was able to neutralize human M-CSF activity, but with less potency. The humanized variant of the antibody was constructed (EP1913028B1).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
