Cat. No.
MABL-2479
Application
Blocking, FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
11B2D10
From
Recombinant Antibody
Specificity
This antibody recognizes and binds the extracellular epitope of NKG2D and blocks the interaction between ligand and receptor.
Alternative Names
CD314; NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; KLRK1
UniProt
P26718
Immunogen
The original antibody was generated by immunizing BALB/c mice with soluble NKG2-D fragments containing amino acids from 64-462 and 123-462.
Application Notes
The NKG2D (Natural Killer Group 2 Member D) protein is an activating receptor that enables NK and CD8+ T cells to recognize and eliminate infected or transformed endogenous cells.However, incorrect regulation of this receptor on immune cells also appears to lead to the development of autoimmune diseases such as type I diabetes, celiac disease, and RA. This antibody positively reacts with NKG2D on CD8-positive T cells and to CD56-positive natural killer cells. The binding was confirmed by FACS analysis (Steigerwald, 2008).
Antibody First Published
US20040038339
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
