Cat. No.
MABL-2589
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Bacillus anthracis
Clone No.
W5
From
Recombinant Antibody
Specificity
This antibody recognizes protective antigen (PA) of anthrax toxin. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane.
Alternative Names
protective antigen; PA; Anthrax toxins translocating protein; PA-83; PA83; anthrax toxin
UniProt
P13423
Immunogen
The original scFv version of this antibody was isolated from a phage display library generated from immunized chimpanzees.
Application Notes
The original scFv version of this antibody was confirmed to strongly bind anthrax protective antigen (PA) via ElISA (Chen et al., 2006; pmid: 16453257).
Antibody First Published
Chen et al. Efficient Neutralization of Anthrax Toxin by Chimpanzee Monoclonal Antibodies against Protective Antigen J Infect Dis. 2006 Mar 1; 193(5): 625–633. PMID:16453257
Note on publication
Describes the generation and characterization of anti-PA and anti-LF anthrax antibodies.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
