Cat. No.
MABL-2608
Application
therapeutic, ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
2F8-10-3
From
Recombinant Antibody
Specificity
This antibody binds human parathyroid hormone-related protein.
Alternative Names
PTHLH; PTH-rP; PTHrP; PLP; PTHrP[107-139]; Parathyroid hormone-like protein
UniProt
P12272
Immunogen
The original antibody was generated by immunizing a human antibody-producing transgenic mouse with human PTHrP.
Application Notes
The original human IgG2 version of this antibody binds parathyroid hormone-related protein with a binding affinity of 0.11 nM. The binding characterization of the human IgG2 version of this antibody towards PTHrP was done using ELISA. Excess PTHrP production causes hypercalcemia, such as tumor-dependent hypercalcemia often caused by PTHrP secreted by tumor cells in large amounts. This human anti-human PTHrP antibody has had a significant suppressive and therapeutic effect on PTHrP- induced hypercalcemia in a malignant hypercalcemia associated with tumor (MAH) model mice (JP2000080100).
Antibody First Published
Nobuaki et al. JP2000080100
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
