Cat. No.
MABL-2628
Application
SPR, ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
PCT Nb1
From
Recombinant Antibody
Specificity
The antibody is specific for PCT. PCT is a protein consisting of 116 amino acids. PCT is the peptide precursor of calcitonin, a hormone that is synthesized by the parafollicular C cells of the thyroid and involved in calcium homeostasis.
Alternative Names
Procalcitonin
UniProt
Immunogen
The original antibody was isolated by panning a camel-derived phage display nanobody library against PCT.
Application Notes
The specificity of the original format of the antibody was confirmed by ELISA analysis (CN104404630A). The binding affinity of the VHH fragment to PCT was measured by surface plasmon resonance (Kd= 12 nM) (Yan et al., 2015; PMID: 25944262).
Antibody First Published
Yan et al. Characterization and applications of Nanobodies against human procalcitonin selected from a novel naïve Nanobody phage display library J Nanobiotechnology. 2015 May 6;13:33. doi: 10.1186/s12951-015-0091-7. PMID:25944262
Note on publication
The paper describes the generation and characterization of the antibody by phage display selection.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.